Reminyl is on the list of essential medications for the treatment for Alzheimer's disease and senile dementia by Alzheimer's type. In complex therapy, the drug inhibits degenerative processes associated with the death of brain cells and facilitates the human condition.
Description of the drug
Reminyl belongs to the pharmacological group of anticholinesterase agents, an inhibitor of the enzyme cholinesterase, responsible for nervous excitement. It slows down the destruction and elimination of chemical compounds in the gray matter cortex that affect the preservation of memory, intellectual activity, cognitive activity, and practical skills, and the ability to self-serve in everyday life.
Partially restores the neural connections of the brain, spinal cord, and ganglia( nerve cells and nodes), the peripheral nervous system (PNS).
It stimulates the secretion of digestive and sweat glands, lowers intraocular pressure, causes pupil constriction, relieves spasm of accommodation, and lowers intraocular pressure.
The main active substance-galantamine hydrobromide is an active component in analogs of the drug (Galantomin-Teva (Israel), Galnora SR (Slovenia), Nivalin (Bulgaria)).
It is available as a solution for injection and marked (G8"), capsules prolonged (prolonging the process), action, inside which are granules of white shades.
The elimination of galantamine is bi-exponential, and the final T1/2 is approximately 7-8 hours. The compound is characterized by rapid absorption from the gastrointestinal tract and slow purification of body fluids and tissues.
In the therapeutic complex, Reminyl (Galantamine) is prescribed for Alzheimer's symptoms (by MayoClinic), mild, moderate, and severe dementia. The drug partially or completely removes psychomotor agitation, manifested in uncontrolled movements, fussiness, irritability, anxiety, panic attacks, unmotivated aggression.
It is effective to use this medication for dementia caused by Parkinson's disease. It increases the processes of excitation in the reflex zones of the spinal cord and brain.
NB! Clinical studies on the correctness of medication for Parkinson's have revealed some significant improvements in the well-being of the subjects. By the end of 2 – 4 months of the course, the patients showed stabilization of movement and gait coordination. A decrease in the frequency of "freezes" and falls was recorded.
In dentistry, Galantamine is indicated for chronic sialoadenitis (inflammation of the parotid salivary gland), motor jaw disorders (with neuritis). Stimulates the secretion of salivary glands.
Conditions common to the body include dizziness, frequent fatigue, and weakness. Usually, after 1 to 2 weeks, the symptoms disappear due to adaptation to Reminyl. To avoid this phenomenon, you can use antiemetics and copious drinking.
Neurology and psychiatry
In the early stages, apathy, depression (rarely - with a tendency to suicide), auditory and visual hallucinations are observed.
Lethargy, headaches, dizziness, drowsiness. Sometimes there may be hemorrhages, strokes, transient ischemic attacks, intercostal neuralgia, localized chills, muscle spasms, numbness of the limbs, sweating.
Hypersomnia (excessive duration of day or night sleep), sensitivity disorders in the form of unexplained burning, tingling, "goosebumps" (paresthesia), nystagmus (acceleration of rotation of the eyeballs).
Often-confusion, asthenic syndrome, worsening of symptoms in Parkinson's disease.
Sometimes patients are prone to irritability and unmotivated aggression.
- Often there is a sharp drop in blood pressure.
- Angina, tachycardia, arrhythmia, or bradycardia (rarely).
- In rare cases-myocardial infarction, and atrioventricular block (AV) of the I degree.
- Peripheral vascular diseases.
- Deep vein thrombosis.
Digestive system and metabolism
Accelerated metabolism and loss of appetite weight loss leading to anorexia.
Digestive disorders (dyspepsia) associated with nausea, vomiting, and diarrhea. Discomfort in the epigastric region, gastrointestinal bleeding.
From the kidneys, pyelonephritis may appear.
Feeling of incomplete emptying of the bladder.
During States of mild and moderate severity, urinary incontinence, nocturia (waking up during the main sleep period two or more times from the desire to urinate) is diagnosed.
Less common are cystitis, pyelonephritis, inability to empty the bladder, kidney failure, and infections of the genitourinary tract.
Revealed fibrocystic mastopathy, mastitis, fibroadenomas of the mammary glands, colpitis, vaginitis.
Ophthalmologists diagnose cataracts, blurred vision, "fluttering of flies", dryness of the eye mucosa, blepharitis, glaucoma in patients. There are local hemorrhages in the retina and conjunctiva.
ENT-manifestations: middle and external otitis, tinnitus, motion sickness (kinetosis), tinnitus, rhinitis.
On the skin and subcutaneous tissues, there is frequent itching, hives, shingles, and dermatoses. There are attacks of hyperhidrosis (sudden, severe sweating), discoloration of the skin, hyperkeratosis (pathological growth of the epidermis, and violation of the peeling of the stratum corneum of the skin).
Rarely occurs alopecia (pathological hair loss on certain parts of the body).
As a rule, unpleasant symptoms pass with long-term treatment, after the body adapts to the medication.
Reminyl is not prescribed to patients with a history of severe renal and hepatic insufficiency, allergic reactions to the main active and additional components.
- With caution, the drug should be used before General anesthesia or local anesthesia;
- Sufferers of bronchial asthma, COPD, bradycardia, arrhythmia, AV block, CCC, unstable angina must warn the doctor about the use of Reminyl.
Use during pregnancy and lactation
During pregnancy, you should refrain from cholesterolemia therapy, because its effects on fetal development have not been investigated. The exception is situations that involve a risk to the health of the expectant mother.
Also, Women receiving this drug should refrain from breastfeeding.
The picture of a pronounced overdose is similar to the symptoms of poisoning with other cholinomimetics. Toxic lesions are expressed from the Central nervous system, parasympathetic NS in the form of muscle weakness, and involuntary twitching.
On the part of the digestive system, there are spastic abdominal pain, profuse salivation, continuous vomiting, incontinence of urine, and feces.
Hypersecretion of the bronchi and trachea, combined with muscle weakness, can cause blockage of the upper respiratory tract and lead to death.
While waiting for an ambulance, it is necessary to carry out supportive measures that are characteristic of poisoning: induce vomiting with a weak solution of potassium permanganate, give absorbents and try to wash the intestines.
You can buy medicine strictly by prescription based on the collected data, and based on the General condition of the patient. Over-the-counter" illegal acquisition and use of "galantamine" can cause irreversible consequences of the patient's condition.